Early-stage biotech investing is not for everyone. The risk is high. The reward is higher. Seasoned investors know the game, but with the abundance of opportunities to invest in early-stage biotech R&D, the attractiveness of the investment must be based on key selection criteria: strong management backed by key opinion leaders in the field, a track record of accomplishing research and clinical milestones, cap table backed by sophisticated and institutional investors, and a patented technology that can disrupt a sufficiently large market. The largest barrier to success is the FDA regulatory approval pathway. Clinical trials are very risky, but this risk can be mitigated. Cytonics’ risk mitigation strategy includes: engaging strategic advisors to lead us through the clinical trial and regulatory process, relying on our previous experience bringing a healthcare technology (the APIC system) to market, seeking continued support from Johnson and Johnson (who owns ~14% of the company), and the prosecution of an airtight IP portfolio that will be attractive to a potential buyer (8 international patents granted, 9 more pending). Importantly, the development of CYT-108 is significantly de-risked compared to other drug development projects because it is based upon the action of the naturally occurring Alpha-2-Macroglobulin (A2M) molecule, which we have already demonstrated to be an effective treatment for osteoarthritis with our commercially and clinically successful APIC system. CYT-108 is a synthetic version of A2M and was developed much like insulin was by Eli Lilly when they engineered a version of the naturally occurring insulin molecule.